abstract：:Nucleic acids have been engineered to participate in a wide variety of tasks. Among them, the enzyme-free amplification modes, enzyme-free DNA circuits (EFDCs), and hybridization chain reactions (HCRs) have been widely applied in a series of studies of bioanalysis. We demonstrated here an ultrasensitive hairpin probe-...

journal_title：Biomacromolecules

authors： Liao Y,Fu Y,Wu Y,Huang R,Zhou X,Xing D

更新日期：2015-11-09 00:00:00

abstract：:Despite numerous strategies involving dynamic covalent bonds to produce self-healing hydrogels with similar frequency-dependent stiffness to native tissues, it remains challenging to use biologically relevant thiol/disulfide exchange to confer such properties to polymeric networks. Herein, we report a new method based...

journal_title：Biomacromolecules

authors： Casuso P,Odriozola I,Pérez-San Vicente A,Loinaz I,Cabañero G,Grande HJ,Dupin D

更新日期：2015-11-09 00:00:00

abstract：:Safe delivery systems that can not only encapsulate hydrophobic drug molecules, but also release them in response to specific triggers are important in several therapeutic and biomedical applications. In this paper, we have designed a nanogel based on molecules that are generally recognized as safe (GRAS). We have sho...

journal_title：Biomacromolecules

authors： Prasad P,Molla MR,Cui W,Canakci M,Osborne B,Mager J,Thayumanavan S

更新日期：2015-11-09 00:00:00

abstract：:Many biological processes are regulated by reversible binding events, with these interactions between macromolecules representing the core of dynamic chemistry. As such, any attempt to gain a better understanding of such interactions, which would pave the way to the extrapolation of natural designs to create new advan...

journal_title：Biomacromolecules

authors： Fernández-Colino A,Arias FJ,Alonso M,Rodríguez-Cabello JC

更新日期：2015-10-12 00:00:00

abstract：:The short average service life of traditional dental composite restorative materials and increasing occurrence of secondary caries adjacent to composite restorations and sealants are necessitating the development of new, longer lasting compositions. Novel monomers and their polymers, reinforcing fillers, and adhesive ...

journal_title：Biomacromolecules

authors： Gonzalez-Bonet A,Kaufman G,Yang Y,Wong C,Jackson A,Huyang G,Bowen R,Sun J

更新日期：2015-10-12 00:00:00

abstract：:Self-assembled hydrogen-bonded networks of the polysaccharide pectin, a mechanically functional component of plant cell walls, have been of recent interest as biomimetic exemplars of physical gels, and the microrheological and strain-stiffening behaviors have been previously investigated. Despite this detailed rheolog...

journal_title：Biomacromolecules

authors： Mansel BW,Chu CY,Leis A,Hemar Y,Chen HL,Lundin L,Williams MA

更新日期：2015-10-12 00:00:00

abstract：:Bone fractures constitute a major cause of morbidity and mortality especially in the elderly. Complications associated with osteoporosis drugs and the age of the patient slow bone turnover and render such fractures difficult to heal. Increasing the speed of fracture repair by administration of a fracture-targeted bone...

journal_title：Biomacromolecules

authors： Low SA,Galliford CV,Yang J,Low PS,Kopeček J

更新日期：2015-10-12 00:00:00

abstract：:Combining poly(ethylene glycol) (PEG) with sequence-defined peptides in PEG-peptide conjugates offers opportunities to realize next-generation drug formulation additives for overcoming undesired pharmacological profiles of difficult small molecule drugs. The tailored peptide segments provide sequence-specific, noncova...

journal_title：Biomacromolecules

authors： Wieczorek S,Schwaar T,Senge MO,Börner HG

更新日期：2015-10-12 00:00:00

abstract：:Periodic patterns resembling spirals were observed to form spontaneously upon unassisted cooling of d-glucaric acid- and d-galactaric acid-based polyamide solutions in N-methyl-N-morpholine oxide (NMMO) monohydrate. Similar observations were made in d-galactaric acid-based polyamide/ionic liquid (IL) solutions. The mo...

journal_title：Biomacromolecules

authors： Rosu C,Russo PS,Daly WH,Cueto R,Pople JA,Laine RA,Negulescu II

更新日期：2015-09-14 00:00:00

abstract：:Placing a physical barrier between the injured site and the adjacent tissues is a very common and highly effective approach to prevent abdominal adhesions in these days. A biodegradable trilayered barrier was fabricated to prevent formation of abdominal adhesions, in which a poly(lactide-co-glycolide)/poly(lactide)-b-...

journal_title：Biomacromolecules

authors： Xia Q,Liu Z,Wang C,Zhang Z,Xu S,Han CC

更新日期：2015-09-14 00:00:00

abstract：:Specific folate receptors are abundantly overexpressed in chronically activated macrophages and in most cancer cells. Directed folate receptor targeting using liposomes is usually achieved using folate linked to a phospholipid or cholesterol anchor. This link is formed using a large spacer like polyethylene glycol. He...

journal_title：Biomacromolecules

authors： Nogueira E,Mangialavori IC,Loureiro A,Azoia NG,Sárria MP,Nogueira P,Freitas J,Härmark J,Shimanovich U,Rollett A,Lacroix G,Bernardes GJ,Guebitz G,Hebert H,Moreira A,Carmo AM,Rossi JP,Gomes AC,Preto A,Cavaco-Paulo A

更新日期：2015-09-14 00:00:00

abstract：:Ferulic acid-based polymers with aliphatic linkages have been previously synthesized via solution polymerization methods, yet they feature relatively slow ferulic acid release rates (∼11 months to 100% completion). To achieve a more rapid release rate as required in skin care formulations, ferulic acid-based polymers ...

journal_title：Biomacromolecules

authors： Ouimet MA,Faig JJ,Yu W,Uhrich KE

更新日期：2015-09-14 00:00:00

abstract：:Selectively spooling single plasmid DNA (pDNA), as a giant polyelectrolyte, into a nanosized toroidal structure or folding it into a rod-like structure has been accomplished by polyion complexation with block catiomers to form polymeric micelles in varying NaCl concentrations. The interactive potency between the pDNA ...

journal_title：Biomacromolecules

authors： Li Y,Osada K,Chen Q,Tockary TA,Dirisala A,Takeda KM,Uchida S,Nagata K,Itaka K,Kataoka K

更新日期：2015-09-14 00:00:00

abstract：:Their physicochemical properties and relatively low cost make cellulose nanocrystals (CNCs) a potential candidate for future large-scale production in many fields including nanomedicine. Prior to a sustained and responsible development as theranostic agents, robust and reliable data concerning their safety, biocompati...

journal_title：Biomacromolecules

authors： Colombo L,Zoia L,Violatto MB,Previdi S,Talamini L,Sitia L,Nicotra F,Orlandi M,Salmona M,Recordati C,Bigini P,La Ferla B

更新日期：2015-09-14 00:00:00

abstract：:Semicrystalline, thermoresponsive poly(2-isopropyl-2-oxazoline) (PIPOx) layers covalently bonded to glass or silica wafers were obtained via the surface-termination of the living polymer chains. Polymer solutions in acetonitrile were exposed to 50 °C for various time periods and were poured onto the functionalized sol...

journal_title：Biomacromolecules

authors： Oleszko N,Wałach W,Utrata-Wesołek A,Kowalczuk A,Trzebicka B,Klama-Baryła A,Hoff-Lenczewska D,Kawecki M,Lesiak M,Sieroń AL,Dworak A

更新日期：2015-09-14 00:00:00

abstract：:Marine mussels tether to seashore surfaces with byssal threads, proteinaceous fibers that effectively dissipate energy from crashing waves. Protein-metal coordination bonds have been proposed to contribute to the characteristic mechanical and self-healing properties of byssal threads; however, very little is understoo...

journal_title：Biomacromolecules

authors： Schmitt CN,Politi Y,Reinecke A,Harrington MJ

更新日期：2015-09-14 00:00:00

abstract：:A novel aptamer modified thermosensitive liposome was designed as an efficient magnetic resonance imaging probe. In this paper, Gd-DTPA was encapsulated into an optimized thermosensitive liposome (TSL) formulation, followed by conjugation with AS1411 for specific targeting against tumor cells that overexpress nucleoli...

journal_title：Biomacromolecules

authors： Zhang K,Liu M,Tong X,Sun N,Zhou L,Cao Y,Wang J,Zhang H,Pei R

更新日期：2015-09-14 00:00:00

abstract：:Infectious diseases remain one of the leading causes of death worldwide despite the tremendous effort devoted to the design and development of antimicrobial agents. However, the decrease in the effectiveness of some antibiotics is often associated with the development of drug resistance by pathogen. This leads to an u...

journal_title：Biomacromolecules

authors： Nguyen D,Nguyen TK,Rice SA,Boyer C

更新日期：2015-09-14 00:00:00

abstract：:Agmatine-containing bioreducible polymer, poly(cystaminebis(acrylamide)-agmatine) (poly(CBA-AG)) was synthesized for gene delivery systems. It could form 200-300 nm sized and positively charged polyplexes with pDNA, which could release pDNA in reducing the environment due to the internal disulfide bonds cleavage. Poly...

journal_title：Biomacromolecules

authors： Choi JY,Ryu K,Lee GJ,Kim K,Kim TI

更新日期：2015-09-14 00:00:00

abstract：:A one-pot synthetic methodology for fabricating stimuli-responsive hemicellulose-based hydrogels was developed that consists of the in situ formation of magnetic iron oxide (Fe3O4) nanoparticles during the covalent cross-linking of O-acetyl-galactoglucomannan (AcGGM). The Fe3O4 nanoparticle content controlled the ther...

journal_title：Biomacromolecules

authors： Zhao W,Odelius K,Edlund U,Zhao C,Albertsson AC

更新日期：2015-08-10 00:00:00

abstract：:In this contribution, a hydrophobically modified polysaccharide derivative is synthesized in an eco-friendly solvent water by conjugation of benzylamine with the backbone of the biopolymer. Owing to the presence of aromatic moieties, the resulting water-soluble polysaccharide derivative self-assembles spontaneously an...

journal_title：Biomacromolecules

authors： Mohan T,Rathner R,Reishofer D,Koller M,Elschner T,Spirk S,Heinze T,Stana-Kleinschek K,Kargl R

更新日期：2015-08-10 00:00:00

abstract：:Alginate-based amphiphilic graft copolymers were synthesized by single electron transfer living radical polymerization (SET-LRP), forming stable micelles during polymerization induced self-assembly (PISA). First, alginate macroinitiator was prepared by partial depolymerization of native alginate, solubility modificati...

journal_title：Biomacromolecules

authors： Kapishon V,Whitney RA,Champagne P,Cunningham MF,Neufeld RJ

更新日期：2015-07-13 00:00:00

abstract：:We report the engineering of intracellular redox-responsive nanoporous poly(ethylene glycol)-poly(l-lysine) particles (NPEG-PLLs). The obtained particles exhibit no toxicity while maintaining the capability to deliver a small interfering RNA sequence (siRNA) targeting the anti-apoptotic factor, survivin, in prostate c...

journal_title：Biomacromolecules

authors： Cavalieri F,Beretta GL,Cui J,Braunger JA,Yan Y,Richardson JJ,Tinelli S,Folini M,Zaffaroni N,Caruso F

更新日期：2015-07-13 00:00:00

abstract：:The thermal conductive properties, including the thermal diffusivity and resultant thermal conductivity, of nonwoven nanocellulose sheets were investigated by separately measuring the thermal diffusivity of the sheets in the in-plane and thickness directions with a periodic heating method. The cross-sectional area (or...

journal_title：Biomacromolecules

authors： Uetani K,Okada T,Oyama HT

更新日期：2015-07-13 00:00:00

abstract：:Encapsulation of hydrophilic cancer drugs in polymeric nanocapsules was achieved in a one-pot process via the inverse miniemulsion periphery RAFT polymerization (IMEPP) approach. The chosen guest molecule was gemcitabine hydrochloride, which is used as the first-line treatment of pancreatic cancer. The resulting nanoc...

journal_title：Biomacromolecules

authors： Utama RH,Jiang Y,Zetterlund PB,Stenzel MH

更新日期：2015-07-13 00:00:00

abstract：:A shortage of available organ donors has created a need for engineered tissues. In this context, polymer-based hydrogels that break down inside the body are often used as constructs for growth factors and cells. Herein, we report imine cross-linked gels where degradation is controllable by the introduction of mixed im...

journal_title：Biomacromolecules

authors： Boehnke N,Cam C,Bat E,Segura T,Maynard HD

更新日期：2015-07-13 00:00:00

abstract：:New pH-responsive polymersomes for active anticancer oligonucleotide delivery were prepared from triblock copolymers. The delivery systems were formed by two terminal hydrophilic blocks, PEG and polyglycerolmethacrylate (poly-GMA), and a central weakly basic block, polyimidazole-hexyl methacrylate (poly-ImHeMA), which...

journal_title：Biomacromolecules

authors： Gallon E,Matini T,Sasso L,Mantovani G,Armiñan de Benito A,Sanchis J,Caliceti P,Alexander C,Vicent MJ,Salmaso S

更新日期：2015-07-13 00:00:00

abstract：:Molecular dynamics (MD) simulations have been applied to study the interactions between hydrophobic and hydrophilic faces of ordered cellulose chains and a single layer of graphene in explicit aqueous solvent. The hydrophobic cellulose face is predicted to form a stable complex with graphene. This interface remains so...

journal_title：Biomacromolecules

authors： Alqus R,Eichhorn SJ,Bryce RA

更新日期：2015-06-08 00:00:00

abstract：:n-Heptyl α-d-mannose (HM) is a nanomolar antagonist of FimH, a virulence factor of E. coli. Herein we report on the construction of multivalent HM-based glycopolymers as potent antiadhesives of type 1 piliated E. coli. We investigate glycopolymer/FimH and glycopolymer/bacteria interactions and show that HM-based glyco...

journal_title：Biomacromolecules

authors： Yan X,Sivignon A,Yamakawa N,Crepet A,Travelet C,Borsali R,Dumych T,Li Z,Bilyy R,Deniaud D,Fleury E,Barnich N,Darfeuille-Michaud A,Gouin SG,Bouckaert J,Bernard J

更新日期：2015-06-08 00:00:00

abstract：:We demonstrate the fabrication of protein·gold nanoparticle (AuNP) nanocomposites in situ, leading to distinct assemblies dependent upon protein secondary structure. In the presence of pentameric coiled-coil proteins C and Q, which contain histidine tags and have helicities of 54 and 65%, respectively, templation of A...

journal_title：Biomacromolecules

authors： Hume J,Chen R,Jacquet R,Yang M,Montclare JK

更新日期：2015-06-08 00:00:00

abstract：:Inflammation plays an important role in symptomatic intervertebral disc degeneration and is associated with the production of neurotrophins in sensitizing innervation into the disc. The use of high molecular weight (HMw) hyaluronic acid (HA) hydrogels offers a potential therapeutic biomaterial for nucleus pulposus (NP...

journal_title：Biomacromolecules

authors： Isa IL,Srivastava A,Tiernan D,Owens P,Rooney P,Dockery P,Pandit A

更新日期：2015-06-08 00:00:00

abstract：:Multifunctional cellulose nanocrystals have been synthesized and applied as a new type of glyconanomaterial in lectin binding and bacterial imaging. The cellulose nanocrystals were prepared by TEMPO-mediated oxidation and acidic hydrolysis, followed by functionalization with a quinolone fluorophore and carbohydrate li...

journal_title：Biomacromolecules

authors： Zhou J,Butchosa N,Jayawardena HS,Park J,Zhou Q,Yan M,Ramström O

更新日期：2015-04-13 00:00:00

abstract：:Polycations often suffer from the irreconcilable inconsistency between transfection efficiency and toxicity. Polymers with high molecular weight (MW) and cationic charge feature potent gene delivery capabilities, while in the meantime suffer from strong chemotoxicity, restricted intracellular DNA release, and low stab...

journal_title：Biomacromolecules

authors： He H,Bai Y,Wang J,Deng Q,Zhu L,Meng F,Zhong Z,Yin L

更新日期：2015-04-13 00:00:00

abstract：:We prepared statistical copolymers composed of 2-methyl-2-oxazoline (MeOx) in combination with 2-butenyl-2-oxazoline (BuOx) or 2-decenyl-2-oxazoline (DecOx) as a basis for polymer analogous introduction of 1,2-aminothiol moieties at the side chain. MeOx provides hydrophilicity as well as cyto- and hemocompatibility, w...

journal_title：Biomacromolecules

authors： Schmitz M,Kuhlmann M,Reimann O,Hackenberger CP,Groll J

更新日期：2015-04-13 00:00:00

abstract：:Polypeptide-based formulations that undergo liquid to hydrogel transitions upon change in temperature have become desirable targets since they can be mixed with cells or injected into tissues as liquids, and subsequently transform into rigid scaffolds or depots. Such materials have been challenging to prepare using sy...

journal_title：Biomacromolecules

authors： Zhang S,Alvarez DJ,Sofroniew MV,Deming TJ

更新日期：2015-04-13 00:00:00

abstract：:RNA-based delivery system for cancer therapy remains a challenge. In this study, a stearyl-peptide (SHR) was synthesized using arginine, histidine, cysteine, and stearyl moieties. Further, the stearyl-peptides were cross-linked by disulfide bonds to obtain cross-linked polypeptides (SHRss) with different molecular wei...

journal_title：Biomacromolecules

authors： Tai Z,Wang X,Tian J,Gao Y,Zhang L,Yao C,Wu X,Zhang W,Zhu Q,Gao S

更新日期：2015-04-13 00:00:00

abstract：:Bionanocomposite materials, combining the properties of biopolymers and nanostructured materials, are attracting interest of the wider scientific community due to their potential application in design of implants, drug delivery systems, and tissue design platforms. Herein, we report on the use of maleimide-coated silv...

journal_title：Biomacromolecules

authors： García-Astrain C,Chen C,Burón M,Palomares T,Eceiza A,Fruk L,Corcuera MÁ,Gabilondo N

更新日期：2015-04-13 00:00:00

abstract：:In this work, cell-responsive polysaccharide hydrogels were prepared by a simple procedure based on the sequential bioconjugation and cross-linking of the polysaccharide backbone with bioactive peptides and poly(ethylene glycol)-bis(thiol) (PEG-(SH)2), respectively. Using thiol-ene reactions, we successfully functiona...

journal_title：Biomacromolecules

authors： Jing J,Fournier A,Szarpak-Jankowska A,Block MR,Auzély-Velty R

更新日期：2015-03-09 00:00:00

abstract：:A lipid bilayer was deposited on a 3 μm diameter polystyrene (PS) bead via hydrophobic anchoring of bicelles containing oxyamine-bearing cholesteric moieties reacting with the aldehyde functionalized bead surface. Discoidal bicelles were formed by mixing dimyristoylphosphatidylcholine (DMPC), dihexanoylphosphatidylcho...

journal_title：Biomacromolecules

authors： Saleem Q,Zhang Z,Petretic A,Gradinaru CC,Macdonald PM

更新日期：2015-03-09 00:00:00

abstract：:Inspired by tea stains, plant polyphenolic tannic acid (TA) was beneficially employed as the primer anchor for functional polymer brushes. The brominated TA (TABr) initiator primer was synthesized by partial modification of TA with alkyl bromide functionalities. TABr with trihydroxyphenyl moieties can readily anchor o...

journal_title：Biomacromolecules

authors： Pranantyo D,Xu LQ,Neoh KG,Kang ET,Ng YX,Teo SL

更新日期：2015-03-09 00:00:00